Stereoselective Synthetic Strategies to (?)?Cannabidiol

(?)-Cannabidiol (CBD) is a non-psychoactive compound that has already found many medical applications, from the treatment of epilepsy to other neurological disorders. (?)-CBD usually extracted Cannabis Sativa, but unfortunately, its isolation among structurally related cannabinoids can be challenging. This, along with increased demand for (?)-CBD, prompted chemists come up synthetic strategies could afford this cannabinoid in good yield and high enantiopurity. Herein, we aim review fundamental employed stereoselective synthesis (?)-cannabidiol, spanning classic approaches automated ones, highlighting challenges encountered total cannabinoid.